In this country, typhoid fever is the most prevalent disease of acute infectious diseases and antibacterial drugs have been used indiscriminately without prescribtion or medical supervision.
Fifty eight Salmonella strains isolated between 1968 and April 1970 from fecal or blood specimens of patients and carriers throughout Chonnam province were screened for resistance to antibacterial agents, R factor, bacteriocinogeny and sensitivity to standard colicins.
Of 58 isolates, 44 strains were identified as S. typhi, 5 strains as S.paratyphi C, respective 2 strains as S. paratyphi A, S. paratyphi B, S. typhimurium and S. seftenberg, and one strainas S. cholerasuis, respectively, indicating the most common serotype is. S. typhi.
Of 58 strains isolated, 13 strains (22. 4%) were resistant to one or more of the antibacterial agents such as streptomycin (SM), tetracycline (TC), ampicillin sodium (AP), chloramphenicol(CP), and kanamycin (KM) The isolates were resistant to SM(13strains), TC and AP(respective 5 strains), CP (3 strains), KM (1 strain), indicating that the strains were most common resistance to SM. No strains were resistant to the agents nalidixic acid.
The multiply resistant strains(10 strains)were more-than the singly resistant strains (3 strains).
Of 13 resistant strains, 10 strains (76.9%) carried R factor. The six different resistance patterns of R factor demonstrated were SM, CP, SM TC, SM AP, SM TC CP, and SM TC AP. Resistance was relatimore common in strains of S. typhimurium than in the other Salmonella serotypes.
None of the isolates produced colicin, whereas 8 strains of the isolates were sensitive´ to one or more of colicin A, B, and V among standard colicins.
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